Statins and risk of diverticular disease: Nested case–control study

Background Statins exert pleiotropic anti-inflammatory effects and may prevent diverticular disease. However, the association remains poorly understood with previous studies obtaining conflicting results. Aims To examine effect of statin on subsequent risk Methods We conducted a nested case–control study in Denmark among respondents (>18 years) 2010 or 2013 Danish National Health Survey. Among these, we identified 8809 cases hospital-diagnosed disease risk-set sampled population controls without Using complete prescription hospital records, used conditional logistic regression to compute odds ratios (ORs) associating use In adjusted analyses, controlled for hospital-based diagnoses, medication other than statins, lifestyle socioeconomic factors. Results The fully OR associated ever (≥1 filling) was 1.19 (95% CI: 1.12–1.27) compared never use. observed no dose–response relation. For example, short-term users (<5 years), 1.18 1.04–1.35) low intensity 1.13 1.01–1.26) high users. long-term (≥5 respective ORs were 1.25 1.13–1.38) 1.11 0.98–1.24). analyses restricting colonoscopy, associations null (OR: 1.01 [95% 0.85–1.20]). Conclusions higher statins could be explained by diagnostic bias. Our did not support protective nor harmful